Endocrine Abstracts

Aim: The aim of our study was to assess the contribution of genetic variation in some previously reported gestational diabetes mellitus (GDM) susceptibility loci and lifestyle parameters to GDM risk.Methods: We performed a case-control study of 278 GDM cases and 179 controls who had filled up special questionnaires concerning their lifestyle habits during the oral glucose tolerance test (OGTT) on the 24–32 week of gestation. The questionnaire consis...

Introduction: Some, but not all, previously published studies suggest that low vitamin D status maybe associated with increased risk of gestational diabetes (GDM). We examined the association of plasma plasma 25-hydroxyvitamin D (25(OH)D) concentration with GDM risk and neonatal macrosomia.Methods: 143 women were recruited before 15 weeks of gestation and were followed-up until delivery. Maternal plasma 25(OH)D concentrations were measured at 8–14 w...

Introduction: Pregnancy is characterized by a progressive insulin resistance (IR). Some, but not all, previously published studies suggest that adipokines are related to insulin resistance in pregnant women and subsequent development of gestational diabetes (GDM).The aim of this study was to investigate the relation between adiponectin, leptin, its ratio and homeostasis model assessment of IR (HOMA-IR) in the first prenatal visit and whether it could be ...

Background and aim: Gestational Diabetes Mellitus (GDM) is often diagnosed at 24-28 weeks of pregnancy when the fetal phenotype is already altered. We aimed to develop a machine learning model based on clinical variables, lifestyle features and genetic markers for GDM prediction in the first trimester of pregnancy based on the 2013 World Health Organization (WHO) criteria.Methods: Using multivariable logistic regression analysis, different models to pred...

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Ovarian fibrosis and altered angiogenesis have been discussed as important factors in the pathogenesis of PCOS. Lifestyle modification is the first step in the treatment of PCOS. However, a specific composition of diet that should be included in a lifestyle change program has not been determined. The aim: Of the study was to compare the effect...

Background: Gestational diabetes mellitus (GDM) is known to predispose offspring to metabolic diseases. However, the underlying mechanisms has not been thoroughly studied yet. The glucocorticoid receptor gene or nuclear receptor sub-family 3, group C, member 1 (NR3C1) may predispose to type 2 diabetes mellitus, metabolic syndrome and depression. NR3C1 gene showed significantly decreased methylation levels in cord blood and placenta from GDM women compared wit...

Background: Understanding the mechanism whereby the intrauterine hyperglycemia in women with gestational diabetes mellitus (GDM) affects the offspring’ predisposition to metabolic and cardiovascular diseases may help prevent their intergenerational transmission. Our aim was to study the effect of the degree and duration of maternal hyperglycemia on the level of expression of genes associated with cardio-metabolic diseases in human umbilical vein endothelial cells (HUVECs)...

Background and aims: Current glycaemic treatment targets for women with gestational diabetes (GDM) are controversial. The aim of the study was to compare the effect of different intensities of glycaemic control in pregnant women with GDM on perinatal outcomes.Materials and methods: Pregnant women in the 8th to 31st week of gestation were randomly assigned to 2 groups per target glycaemic levels: GDM1 (very tight glycaemic targets, fasting blood glucose (...

Background and Aims: The gut microbiome has been shown to differ between healthy individuals and those with diabetes and even in women with gestational diabetes mellitus (GDM). This raises the question of its role in postprandial glycemic response (PPGR). We aimed to evaluate the impact of microbiome features in PPGR in women with GDM and healthy pregnant women.Methods: We obtained stool samples for 96 pregnant women (65 GDM, 31 control), previously recr...